Fig. 5: Ad26 HIV-1 Env boosts tier 2 Clade C neutralizing antibody responses. | Nature Communications

Fig. 5: Ad26 HIV-1 Env boosts tier 2 Clade C neutralizing antibody responses.

From: CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Fig. 5

Longitudinal kinetics of serum neutralizing activity of Env-CoP2 (N = 9) and control (N = 4) groups through the course of the three-dose particle immunization phase (weeks 10, 18) into the Ad26 boost phase (week 34, 36) against the clade C pseudovirus panel of n = 10 strains and Murine Leukemia Virus (MLV) Env pseudotype as negative control. Each color denotes one animal and numbers represent animal ID. Gray regions indicate the Ad26 boost phase. Dotted lines represent the neutralization assay lower limit of detection (LLOD) of 20 Serum ID50 and values below the LLOD were set to 1/2 the LLOD of 10 serum ID50 for plotting and analysis. Source data are provided as a Source Data file.

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