Table 4 Univariate and multivariate Cox regression analysis of overall survival (OS) in the integrated study cohort

From: Enhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights

Variables

Univariate

Multivariate

P value

HR (95% CI)

P value

HR (95% CI)

Imaging Subtypes

High – Risk

Reference

Intermediate - Risk

0.015*

0.58 (0.37–0.90)

0.136

0.68 (0.41–1.13)

Low - Risk

0.000123 ***

0.43 (0.27–0.66)

0.025*

0.52 (0.29–0.92)

Age

0.009*

1 (1–1)

---

---

Male vs Female

0.005**

1.7 (1.2–2.5)

---

---

Non-Smoker vs Smoker

0.104

1.5 (0.92–2.5)

---

---

Histologic type a

0.000693 ***

0.52 (0.36–0.76)

0.005**

0.55 (0.36–0.83)

Treatment type b

0.023*

1.6 (1.1–2.3)

0.33

1.24 (0.81–1.90)

Metabolic tumor volume (MTV)

0.001**

1.4 (1.1–1.7)

0.175

1.88 (0.75–4.75)

Total Lesion Glycolysis (TLG)

0.019*

1 (1–1)

0.476

0.97 (0.91–1.05)

SUV (max)

0.116

1 (1–1)

0.364

0.99 (0.96–1.01)

SUV (mean)

0.092

1 (0.99–1.1)

---

---

Tumor volume

0.004**

1.2 (1.1–1.3)

0.262

0.81 (0.56–1.17)

  1. a Adenocarcinoma vs other types (reference).
  2. b Chemotherapy vs other types (reference).
  3. * P < 0.05; ** P < 0.01; *** P < 0.001. All statistical tests were two-sided, with P < 0.05 indicative of a statistically significant difference. Source data are provided as a Source Data file.
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