Fig. 2: Consistent changes of CRC-associated microbes in old- and young-onset patients in two independent cohorts.
From: Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer
a Two-dimension scatter plot shows the overall distribution of Fudan and Guangzhou samples. Principle coordinate analysis (PCoA) was performed based on the Bray–Curtis distance calculated from the abundance profile at species level. Each point represents one sample. Samples from Fudan and Guangzhou cohorts are in red and blue, respectively. Circles are control samples, while triangles are CRC samples. Violin plots show values of PCoA axis 1 (b) PCoA axis 2 (c), and Shannon index (d) across different groups. The thick horizon line indicates the 50% percentile. P values on the top were calculated by two-side Wilcoxon rank-sum test. e Four well-known CRC-enriched species significantly enriched in both oCRC and yCRC patients at false discovery rate (FDR) adjusted P < 0.05. The sample size of each group is the same as a. The relative abundance is in log10 scale and zeros were replaced by a small value. The box plots show the median (thick line), interquartile range (box limits), 1.5× the interquartile range span (whiskers), and outliers (dots). Diamond shape indicates the mean abundance.
