Fig. 2: Genomic characteristics of primary tumors. | Nature Communications

Fig. 2: Genomic characteristics of primary tumors.

From: Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

Fig. 2

Patient primary tumors (n patients = 43; n tumors = 46) are split based on histology and subsequently whether a PDX model was generated from any tumor region (PDX) or not (no PDX). Within each category, tumors are ordered according to their total mutation burden. Top panel: total number of coding and non-coding mutations including single nucleotide variants (SNVs), dinucleotide and indel alterations. Bars are colored by the clonality status of alterations. Second panel: proportion of truncal and subclonal mutations. Third panel: proportion of copy number alterations that were truncal or subclonal. Fourth panel: proportion of mutational signatures as estimated across all mutations. Bottom panel: driver alterations on a per tumor basis. The genes shown are mutated in more than three tumors in this patient cohort. Mutations are colored by the clonal status of alterations. LUAD—lung adenocarcinoma; LUSC—lung squamous cell carcinoma; CN—copy number; MMR—mismatch repair.

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