Fig. 4: Suppressive gene expression programs in organ-infiltrating donor Tregs upon GvHD induction. | Nature Communications

Fig. 4: Suppressive gene expression programs in organ-infiltrating donor Tregs upon GvHD induction.

From: Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Fig. 4

a–c Scatter plots of global gene expression (logCPM > 1, logRPKM > 1) comparing donor Treg re-isolated from the indicated organs after BMT ± Tconv. Differential genes are highlighted categorically by coloring (padj.|FC|>1.5 > 0.05, qlf-test), as indicated below (a, b). d Heatmap presenting hierarchically clustered and scaled expression data of genes associated with suppressive Treg functions which are schematically depicted on top of the plot (a: allo, p: poly, +: CD62L+, −: CD62L−). a–d Source data are provided as a Source Data file.

Back to article page