Fig. 2: Inter-protomer interactions of the E6AP/E6 complex.
From: Structural insights into the functional mechanism of the ubiquitin ligase E6AP
a Overall interaction between two E6AP/E6 protomers in the Att1 state. The inter-protomer interactions are mainly mediated by the α1-helix and the N-helix (red box) and by the E6 and C-lobe of E6AP (black box). The orientation, the coloring and the method of naming are the same as that presented in Fig. 1b. b Zoomed-in view of the inter-protomer interaction between E6 and the C-lobe. E6AP in the protomer 2 is shown in surface representation. c, d Detailed interactions between the two E6AP/E6 protomers mediated by E6 and the E6AP C-lobe. The interactions are formed mainly by E6N (blue box, c) and E6C (red box, d) of E6 in protomer 1 with the C-lobe of E6AP in protomer 2. e Zoomed-in view of the regions outlined by the red line in a. Lipophilicity potential surface (hydrophobic, gold; hydrophilic, cyan) and ribbon presentations show the detailed interactions between two E6AP/E6 protomers mediated by the α1-helix.
