Fig. 3: Substrate scope and synthetic transformations for the iron-catalyzed asymmetric C–H alkylation. | Nature Communications

Fig. 3: Substrate scope and synthetic transformations for the iron-catalyzed asymmetric C–H alkylation.

From: Iron-catalyzed stereoselective C–H alkylation for simultaneous construction of C–N axial and C-central chirality

Fig. 3

a N-substituent pattern. b Robustness with respect to indoles. c Scope of alkenes. d Scale-up and late-stage transformations. Reaction conditions: 1 (0.1 mmol), 2 (0.15 mmol), Fe(acac)3 (10 mol%), L5 (10 mol%), CyMgBr (1 M in THF, 50 mol%) and TMEDA (0.2 mmol) were stirred in Et2O (0.2 mL) at room temperature for 72 h under N2, then added HCl aq. (1 M, 1.0 mL) and stirred for 2 h. Yields are those of the isolated products. The diastereomeric ratio (d.r.) was determined by 1H NMR spectroscopy. The enantiomeric excess (e.e.) was determined by HPLC.

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