Fig. 1: Inflammation, neurogenesis, and bony remodeling during OA pathogenesis and progression. | Nature Communications

Fig. 1: Inflammation, neurogenesis, and bony remodeling during OA pathogenesis and progression.

From: Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints

Fig. 1

a, b Representative histology images of osteoarthritic knee joint sections stained by hematoxylin and eosin. The joints were collected 2 (a) or 4 weeks (b) after the DMM surgery. Arrowheads, inflamed synovial tissues. c Representative histology images of osteoarthritic knee joint sections stained by alcian blue/hematoxylin & orange G. The joints were collected 4 weeks after the DMM surgery. Arrowheads, synovial hyperplasia and osteochondral formation. Scale bar, 100 μm. n = 6 joints. d–h Representative immunohistochemistry (IHC) images of osteoarthritic knee joint sections stained by individual antibodies as shown. The joints were collected 4 weeks after the DMM surgery. Arrowheads positively IHC signals. Scale bar, 100 μm. Data are presented as mean values ± SD. n = 5 independent experiments. Unpaired two-sided Student’s t-test. ****p < 0.0001. Source data are provided as a Source Data file.

Back to article page