Fig. 5: Pathogenicity and replication of A/bat/Egypt/381-OP/2017 and A/mallard/Alberta/17/1991 viruses in ferrets.

A, B Ferrets (n = 3/group) were inoculated i.n. with 10⁶ EID₅₀ of each virus studied. Each ferret was paired with an individual naïve ferret at 24 h post inoculation. Viral titers in nasal washes from individual inoculated ferrets (D; red), direct-contact ferrets (DC; blue), and airborne-contact ferrets (AC; green) on the days post inoculation or post contact were determined and presented as the log₁₀EID₅₀/mL. The mean values +/− SD of body weight loss (C, D) and changes in body temperature (E, F) of individually inoculated (D), direct-contact (DC), and airborne-contact (AC) ferrets up to 12 days post inoculation or post contact and the data are presented as mean values +/− SD using GraphPad Prism. Source data are provided as a Source data file.