Fig. 7: A schematic model showing JAK2-CARM1 axis.
From: Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity
JAK2-V617F mutant kinase, when activated by JAK2, JAK1, or TYK2, strongly phosphorylates CARM1-Y149 and -Y334, increasing its methyltransferase activity and the asymmetrical dimethylation of its substrates, including histone 3 and RUNX1. CARM1 phosphorylation promotes cell-cycle progression and inhibits apoptosis, and regulates the genes associated with stemness (BMI-1).
