Fig. 2: The 15Kb region contains CTCF TAD boundary.
From: TAD boundary deletion causes PITX2-related cardiac electrical and structural defects
Annotation of the 4q25 region with Hi-C map interaction profile from hiPSC-CM WT. Dashed triangles delimit the PITX2-TAD, Non-coding-TAD, ANK2-TAD. Coding genes are represented in blue and non-coding genes in green and 7 Deletions sizes are represented in different horizontal color lines: red/Family#1 (chr4:112555060-112570371), green/Family#2, brown/Family#3, yellow/Family#4, Blue/Family#5, dark blue/Family#6 and purple/Family#7. ATAC-seq tracks from adult human ventricular tissue from CARE database, ATAC-seq from hiPSC-CM WT, CUT&RUN tracks from hiPSC-CM WT using H3K27ac, H3K4me3 and H3K4me1 and CTCF antibodies are displayed. Zoom in of the 15Kb region annotated with ATAC and CUT&RUN CTCF tracks are represented in the bottom panel. The blue line highlights the open region containing the CTCF binding sites. Black arrows represent CTCF binding site orientation. Genome tracks were generated using UCSC Genome browser with the reference genome assembly hg19.
