Fig. 5: The mutually exclusive expression of the lncRNA Playrr and Pitx2 is disrupted in the DelB SAN.
From: TAD boundary deletion causes PITX2-related cardiac electrical and structural defects
a RNA-seq datasets showing that Playrr is expressed in the embryonic day (E)14.5 sinoatrial node (SAN) and less so in the E14.5 right atrium (RA) and in the prenatal human SAN at 9 weeks. Genome tracks were generated using UCSC Genome browser with the reference genome assembly mm10. b Playrr expression level normalized to Myh6 in the mouse SAN (n = 3) and RA (n = 3) at E14.5, postnatal day P4 and P14 (data from ref. 20). Error bars represent SD. c PLAYRR expression level normalized to MYH6 in the human SAN (n = 2) and RA (n = 2) at 9/12 weeks of gestation (data from ref. 28). d Playrr and Pitx2 expression in adult WT (n = 8) and DelB (n = 7) micro-dissected SAN normalized to Myh6. Error bars represent SD. Source data are provided as a Source Data file.
