Table 1 Summary of 17 previously unreported loci

From: Large-scale cross-ancestry genome-wide meta-analysis of serum urate

SNP info				GWAS catalog			GTEx
SNP	Position	Effect	P value	Consequence	Mapped gene	Reported trait	Gene	Tissue
rs2992756^b	1:18807339	0.0132	1.15 × 10⁻⁸	Intergenic	KLHDC7A IGSF21	Breast cancer eGFR	KLHDC7A	Thyroid Liver
rs4129858^b	1:183004334	−0.0131	2.73 × 10⁻⁹	Intron	LAMC1	Blood protein levels Type 2 diabetes	LAMC1 LAMC1-AS1	Artery (Tibial) Adipose (Subcutaneous)
rs6708702^b	2:137074132	0.015	3.19 × 10⁻⁹	Intergenic	UBBP1	eGFR BUN	THSD7B	Artery (Aorta)
rs12623489^a	2:240222564	−0.0195	1.12 × 10⁻⁸	Intron	HDAC4	Triglycerides HDL eGFR SBP DBP
rs13096863^a	3:64651920	−0.0147	6.51 × 10⁻⁹	Intron	ADAMTS9	Waist-hip ratio ABSI Type 2 diabetes Hip circumference SBP DBP CAD BFP BUN Pulse pressure	ADAMTS9	Cells (Cultured fibroblasts)
rs13100870	3:88099788	−0.0196	9.43 × 10⁻⁹			BMI	C3orf38	Artery (Tibial) Adipose (Subcutaneous)
rs34221697^a	3:195635432	0.0463	3.20 × 10⁻⁹	nc-transcript variant 2KB upstream variant	TNK2-AS1 TNK2	BUN eGFR SCL	TNK2	Artery (Tibial) Adipose (Subcutaneous)
rs4647939^a	4:1019312	0.015	8.85 × 10⁻¹¹	3′-UTR	FGFRL1	Type 2 diabetes eGFR	UVSSA FGFRL1 CRIPAK	Artery (Aorta) Artery (Tibial) Thyroid
rs9395816	6:52637594	−0.0154	5.67 × 10⁻⁹			Triglyceride Serum urea level	GSTA1 GSTA2	Adrenal Gland Liver
rs125124^b	7:130584684	0.0127	4.00 × 10⁻⁸	Intron	LINC00513 LINC-PINT	BCC SAL STP	LINC-PINT	Cells (Cultured fibroblasts)
rs17616958^a	10:82137461	−0.0234	3.60 × 10⁻⁹			COPD	MBL1P PLAC9	Artery (Tibial) Adipose (Subcutaneous)
rs34869311	11:15769438	0.015	3.19 × 10⁻⁹	Intron	LOC105376567
rs529343^a	11:77843719	0.0159	2.82 × 10⁻⁸	Intron	ALG8	DBP BMI	NDUFC2-KCTD21	Heart (Atrial Appendage) Adipose (Subcutaneous) Brain (Cortex)
rs12422756^a	12:93789526	0.0185	1.99 × 10⁻⁹	Intron	NUDT4	Blood cell related	UBE2N NUDT4	Cells (Cultured fibroblasts)
rs112533663	13:40767072	0.0199	2.20 × 10⁻¹¹	Intron	LOC124903162		LINC00332 FOXO1	Pancreas Cells (Cultured fibroblasts)
rs73176948^b	13:41611271	−0.0286	7.90 × 10⁻⁹	Intron	ELF1	AST ALT	WBP4	Heart (Left Ventricle) Adipose (Subcutaneous) Thyroid
rs1518149^b	18:40732054	−0.0123	2.35E−08

SNP single-nucleotide polymorphism, GWAS genome-wide association study, eGFR estimated glomerular filtration rate, HDL high-density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure, ABSI a body shape index, BFP body fat percentage, CAD coronary artery disease, BUN blood urea nitrogen levels, SCL serum creatinine levels, BCC basal cell carcinoma, SAL serum albumin levels, STP serum total protein level, COPD chronic obstructive pulmonary disease, BMI body mass index, CRP C-reactive protein, AST aspartate aminotransferase, ALT alanine aminotransferase, eQTL expression quantitative trait loci.
^aMapped genes and eQTL genes are associated with reported traits.
^bLead SNP of loci is associated with reported traits.

Back to article page

Table 1 Summary of 17 previously unreported loci

Search

Quick links