Fig. 4: In silico immune infiltration analysis and expression levels of immune checkpoints. | Nature Communications

Fig. 4: In silico immune infiltration analysis and expression levels of immune checkpoints.

From: An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma

Fig. 4

a Relative proportions of seven types of immune cells in pediatric benign (PB, N = 83) and pediatric malignant (PM, N = 85) samples imputed by CIBERSORTx. Boxes are first and third quartiles, the center line is median, whiskers are ±1.5 interquartile range, and dots are individual data points. Abundance outliers and missing values are not included in the boxplot, throughout Fig. 4. b Representative multiplex immunohistochemistry staining in PB (N = 10) and PM samples (N = 10). The scale bar represents 50 μm. c The protein expression abundances of poliovirus receptor (PVR) and interleukin 10 receptor B (IL10RB) in PB (N = 83), PM-NR (non-recurrence, N = 73) and PM-R (recurrence, N = 12) groups. The significance throughout Fig. 4 is determined by two-sided Welch’s t test.

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