Fig. 3: ST analyses demonstrate decreased presence of early RPCs in the ciliary margin zone as development proceeds from 10 to 13 PCW. | Nature Communications

Fig. 3: ST analyses demonstrate decreased presence of early RPCs in the ciliary margin zone as development proceeds from 10 to 13 PCW.

From: Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina

Fig. 3

A–C Spatial localisation of all cell clusters identified from the ST analyses. Four sections from each eye sample were processed for ST analyses. D The CMZ clusters are shown for each developmental stage. E Early and late RPC gene expression signatures superimposed to the spatial images of each eye specimen. F, G Violin plots showing early (F) and late (G) RPCs aggregate expression scores across four developmental stages, demonstrating the reduction of early RPCs during development. H Early RPCs reach a peak at 7.5-8 PCW and then decline from 10 PCW onwards in the human developing retina. The ratio of early to late RPCs is inferred from the scRNA-Seq data.

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