Fig. 1: The synthetic methods of hindered ether. | Nature Communications

Fig. 1: The synthetic methods of hindered ether.

From: Diastereo-divergent synthesis of chiral hindered ethers via a synergistic calcium(II)/gold(I) catalyzed cascade hydration/1,4-addition reaction

Fig. 1

a The traditional Williamson method for the synthesis of ethers. b Baran’s decarboxylative etherification method for the synthesis of hindered ethers. c Cu-catalyzed enantioconvergent substitution reaction of a-haloamides with oxygen nucleophiles to a-oxygenated amides. d This work: Enantio- and diastereo-divergent Ca(II)/Au(I) synergistic catalysis for synthesis of chiral hindered ether.

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