Fig. 5: Divergent synthesis of all four isomers of chiral hindered ether 3b or 4a. | Nature Communications

Fig. 5: Divergent synthesis of all four isomers of chiral hindered ether 3b or 4a.

From: Diastereo-divergent synthesis of chiral hindered ethers via a synergistic calcium(II)/gold(I) catalyzed cascade hydration/1,4-addition reaction

Fig. 5

All reactions were carried out on a 0.15 mmol scale with 1 eq precursor of 1b, 1.05 eq 2a, 10 mol% of (S)-Ca[A]2 and 5 mol% of (R)-L3[(NCMe)AuSbF6] or 2.5 mol% of (R)-L6[(NCMe)AuSbF6]2 in DCE (1 mL) at −25 °C. Isolated yield. d.r. was determined by crude 1H-NMR and ee values were determined by chiral HPLC.

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