Fig. 3: Premature CD4+ and CD8 + T cell receptor (TCR) repertoire skewing in HIV-exposed uninfected infants (iHEU) relative to HIV-unexposed uninfected infants (iHUU).

A Boxplots comparing Inverse Simpson TCR diversity scores between iHUU and iHEU at birth (BTH) and weeks (WK) 4, 15 and 36. B Boxplots comparing Chao1 TCR clonotype richness between iHUU and iHEU at BTH and WK4, 15 and 36. All boxplots used the standard Tukey’s representation with the central line depicting the median, the upper and lower lines represent the 75th and 25th percentile respectively, and the whiskers mark the boundary at 1.5 times of the 75th and 25th percentile (*p < 0.05, **p < 0.01 and ***p < 0.001; Two-sided Wilcoxon). C Spearman’s rank correlation between naive CD4⁺ and CD8⁺ T cell Inverse Simpson scores and frequencies of CD4⁺ and CD8⁺ T cell clusters respectively. *adjusted p < 0.05, FDR used to correct for multiple comparisons. D GLIPH analysis showing antigen specificity that were significantly enriched in iHUU relative to iHEU and in naïve relative to memory CD4⁺ and CD8⁺ T cell subsets. Sample size for each group is shown in Fig. S1.