Fig. 4: Association of vaccine antibody responses to immune cell phenotypes.
From: Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants
A Comparing IgG levels against pertussis between HIV-exposed uninfected infants (iHEU) and HIV-unexposed uninfected infants (iHUU), grey shaded area indicate threshold IgG levels for protective pertussis vaccine response. B Boxplots comparing rotavirus specific IgA titres between iHEU and iHUU at week 36. All boxplots used the standard Tukey’s representation with the central line depicting the median, the upper and lower lines represent the 75th and 25th percentile respectively, and the whiskers mark the boundary 1.5 times of the 75th and 25th percentile (*p < 0.05, **p < 0.01 and ***p < 0.001; Two-sided Wilcoxon). C, D Spearman’s correlation of FlowSOM clusters abundances for NK cells, CD4+ and CD8+ T cells to anti-pertussis IgG and anti-rotavirus IgA respectively measured at week 15 and 36. *adjusted p < 0.05, FDR used to correct for multiple comparisons.
