Fig. 3: Cytokine and T cell differentiation profiles. | Nature Communications

Fig. 3: Cytokine and T cell differentiation profiles.

From: Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma

Fig. 3

a Differential cytokine expression from baseline compared to post T-VEC injection represented as a heatmap and expressed as log2-fold change compared to V1. Increasing expression represented in orange gradient, no changes shown as white, and decreasing expression shown in blue gradient compared to V1. b Differentiation of CD4 subsets in memory CD4 (T helper cell (Th), T regulatory cell (Treg), central memory (CM), transitional memory (TM), effector memory (EM)) over time represented as a heatmap and expressed as log2-fold change compared to V1. Increasing expression represented in orange gradient, no changes shown as white, and decreasing expression shown in blue gradient compared to V1. c Differentiation of CD8 subsets in memory CD8 (central memory (CM), transitional memory (TM), effector memory (EM), T effector memory CD45RA + (TEMRA)) over time represented as a heatmap and expressed as log2-fold change compared to V1. Increasing expression represented in orange gradient, no changes shown as white, and decreasing expression shown in blue gradient compared to V1. d, e Expression of activation markers at V1 and V2 vs HD in memory CD4 (d) and in memory CD8 (e). Gray bar shown as mean ± SD of individual data points corresponds to reference frequencies from HD (N = 74).

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