Fig. 5: CD8 activation. | Nature Communications

Fig. 5: CD8 activation.

From: Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma

Fig. 5

a, b, Proportion of CD38/ GrzB expression (a) and CD38/ Bcl-2 expression (b) in CD8 memory, central memory (CM), and effector memory (EM) over time shown as stacked barplots. For (a), red bar represents CD38- Bcl2 + , light blue bar represents CD38+ Bcl2 + , green bar represents CD38+ Bcl2-, dark blue bar represents CD38- Bcl2- and for (b), red bar represents CD38- GrzB + , light blue bar represents CD38+ GrzB + , green bar represents CD38+ GrzB-, dark blue bar represents CD38- GrzB-. c, Activation and co-inhibitory profile of CD8 CM and EM subsets represented as a heatmap and expressed as log2-fold change compared to V1. Increasing expression represented in orange gradient, no changes shown as white, and decreasing expression shown in blue gradient compared to V1.

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