Fig. 3: ADIP cells ameliorate blood glucose homeostasis in mice following low dose streptozotocin treatment.

a Graph showing average weekly blood glucose (BG) measurements in wild-type mice treated with low-dose STZ. (green line, BG < 300, n = 5), (red line, BG > 300, n = 5), and (blue line, FAKi treated BG > 300, n = 10). b Graph showing average weekly blood glucose measurements in ElaCreERT2;R26^Tom mice treated with low dose STZ, which reached 300 mg/dl (n = 4) showing that mice that received vehicle (n = 2) did not recover (red lines). Among FAKi-treated mice (n = 2), one was euthanized a week into treatment (green line, corresponding to c), whereas the other mouse showed improved BG values and was euthanized 4 weeks post-FAKi treatment (blue line, corresponding to d). c, d Fluorescent imaging of Tomato in conjunction with insulin and amylase on tissues obtained from ElaCreERT2,R26^Tom mice treated with low dose STZ (n = 4) followed by FAKi or vehicle (n = 2 per group). Mice were euthanized either 1 week into FAKi treatment (c), (n = 1), or 4 weeks after FAKi treatment cessation (d), (n = 1). Random blood glucose was checked daily at the same time to calculate the average weekly BG in (a, b). Arrowheads in (c) and arrows in (d) show Tom⁺/Ins^- or Tom⁺/Ins⁺ cells, respectively. Data in (a) is presented as mean ± SD. Scale bar = 20 μm. Source data are provided as a Source data file.