Fig. 5: FAKi treatment ameliorates blood glucose homeostasis in a diabetic NHP.
From: Acinar to β-like cell conversion through inhibition of focal adhesion kinase
a Graph showing the average total weekly exogenous insulin requirements based on daily measurements in NHPs treated with STZ (n = 4) or STZ followed by FAKi treatment (n = 1). The blue bar on the x-axis denotes the period of FAKi treatment. b Graph showing the average weight of the FAKi-treated diabetic NHP (n = 1), at different occasions during indicated timepoints, including Pre-STZ treatment, Post-STZ treatment, and Post-FAKi treatment. c–e Immunofluorescent imaging for detection of insulin and glucagon of representative islets obtained from the indicated cohorts (n = 1 per group). f β-cell area quantification in the indicated cohorts. n = 1 NHP in each cohort. Data is presented as mean ± SD. Statistical analysis was performed using one-way ANOVA followed by Holm-Sidak test for multiple comparisons in (b). Scale bar = 20 μm. Source data are provided as a Source data file.
