Fig. 8: Heterozygous deletion of Ptk2 in acinar cells leads to conversion of acinar cells into insulin-producing cells.

a Fluorescent imaging of Tomato in conjunction with insulin and amylase on tissues obtained from ElaCreERT2,R26^Tom, Fak^fl/wt (ETF^fl/wt) mice 1 month post tamoxifen treatment showing Tom⁺/insulin⁺ cells outside the endocrine islets (arrows). b, c Fluorescent imaging of Tomato in conjunction with insulin and amylase on tissues obtained from ElaCreERT2,R26^Tom, Fak^wt/wt (ETF^wt/wt) (b) or ETF^fl/wt (c) mice 1 month post tamoxifen treatment showing Tom⁺/insulin⁺ cells within the endocrine islets of ETF^fl/wt mice. d Quantification of islets containing Tom⁺ cells in the ETF^fl/wt mice. Arrows in (a) show some Tom⁺/Ins⁺ cells outside the islets. Arrows in (c) show Tom⁺/Ins⁺ cells within the islets. The bottom panel in (c) is a higher magnification of the cells marked by arrowhead in (c). n = 5 mice from 3 independent experiments. Data in (d) is presented as mean ± SD. Scale bar = 20 μm. Source data are provided as a Source data file.