Fig. 4: The effect of NS132 on HSQC NMR of 15N-labeled αS after incubation with αS fibers. | Nature Communications

Fig. 4: The effect of NS132 on HSQC NMR of 15N-labeled αS after incubation with αS fibers.

From: Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson’s phenotypes

Fig. 4

a A model for the proposed interaction of αS monomer with αS fibers. b The proposed binding interaction sites of αS fibers on the αS monomer residues. The comparison of the HSQC NMR of the 70 µM 15N-labeled αS in the absence (red) and presence (green) of αS fibers after 24 h (c) and 40 h (d). The comparison of the HSQC NMR of the premixed solution of 70 μM 15N-labeled αS + αS fibers in the absence (red) and presence (green) of equimolar NS132 after 24 h (e) and 40 h (f).

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