Fig. 2: Volcano plot for the prospective associations of circulating proteins with risk of cancer. | Nature Communications

Fig. 2: Volcano plot for the prospective associations of circulating proteins with risk of cancer.

From: Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank

Fig. 2

Volcano plot displaying the results from the prospective observational analyses of 1463 proteins with cancer risk. Top protein-cancer associations plotted with point size indicating the number of ENT significant protein-cancer associations. The point colour represents the cancer site. Hazard ratios per SD for cancer risk are plotted on the x-axis while –log10 p-values are plotted on the y-axis. Protein names and hazard ratios are labelled to highlight a selection of associations significant after correction for multiple testing (p < 0.05/639). Hazard ratios and 95% confidence intervals for each cancer site were separately estimated using two-sided Cox proportional hazards regression models. N- number, ENT – effective number of tests. Source data are provided as a Source Data file.

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