Fig. 4: Mirror Manhattan plot for the association of genetically predicted protein concentrations and cancer risk using cis-pQTL and exome scores.
This mirror Manhattan plot displays the results of each cis-pQTL (top) in the full exome-sequencing cohort within the UK Biobank across European samples for proteins passing correction for multiple testing in the observational results on cancer risk. The y-axis represents the -log10 p-values. The bottom of this plot contains the exome-wide score results for genetically predicted proteins. Markers coloured in grey represent results that did not reach the conventional p < 0.05 significance threshold, while markers in blue represent conventionally significant results. If a cis-variant or an exome-wide score passes Bonferroni significance, those markers are coloured by the cancer site of association. Odds ratios were estimated using logistic regression models to investigate the association of each genetically predicted protein with cancer risk per standard deviation increase. Cis-variants were adjusted to be on the same scale. cis-pQTL - cis protein quantitative trait loci, NHL – Non-Hodgkin lymphoma. Source data are provided as a Source Data file.
