Fig. 10: Mechanism of action of LncDACH1 mediated AVF NIH.

KLF9 was downregulated in AVF NIH, leading to downregulation of LncDACH1, which in turn promoted SRPK1 and HSP90 to reactivate p-AKT. LncDACH1 inhibited SRPK1 nuclear translocation may through enhancing the binding ability between HSP90 and SRPK1.