Fig. 4: Conservation analysis of the dimer-dimer interface in the AlbAB filament.
a AlbAB filament in transparent surface representation. The dimer-dimer interfaces are shown as spheres colored according to sequence conservation. FMN is shown as well colored according to atom type. AlbA2 dimers are outlined in blue and AlbB2 dimers in black. b Different perspectives of an AlbA2-AlbB2 tetramer highlighting amino acid conservation at the dimer-dimer interface and surrounding the FMN cofactor. c Conservation scores calculated with ConSurf99,100,101 for the residues identified at the dimer-dimer interface. Only one AlbB subunit contributes to the interface while both AlbA subunits are involved. The residues of the AlbA subunit that carries the FMN cofactor at any given interface are highlighted (*).
