Fig. 4: Sex-interacting eQTL (si-eQTL) are shared across brain regions. | Nature Communications

Fig. 4: Sex-interacting eQTL (si-eQTL) are shared across brain regions.

From: Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus

Fig. 4

A UpSet plot displaying overlap across brain regions for si-eQTL (local false sign rate [lfsr] < 0.05). Blue is shared across the caudate nucleus (n = 399; 126 female and 273 male), DLPFC (dorsolateral prefrontal cortex; n = 377; 121 female and 256 male), and hippocampus (n = 394; 126 female and 268 male); orange, shared between two brain regions; and black, unique to a specific brain region. B Heatmap of the proportion of gene level si-eQTL sharing with sign match (left), within a factor of 0.5 effect size (middle), and within a factor 0.99 effect size (right). C Functional enrichment plot of the ten most significant gene ontology-terms (biological processes) of eGenes for the caudate nucleus (blue), DLPFC (yellow), and hippocampus (gray).

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