Fig. 5: Synthetic applications.
From: Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes
a Gram-scale experimental results. b Continuous-flow synthesis applications in dechlorinative borylation at the 1 mmol scale. aThe reaction was performed on a 10 mmol scale with 0.5 mol% catalyst loading TR, residence time; V, volume. c Diversification of products: (i) 3, allyl chlorides, NaOtBu, THF, rt, 3 h. (ii) Pd(PtBu3)2 (5 mol%), 3, 4-iodoanisole, KOH, H2O/1,4-dioxane, rt, 2 h. (iii) Pd(PtBu3)2 (5 mol%), 3, methyl 4-iodobenzoate, KOH, H2O/1,4-dioxane, rt, 2 h. (iv) 30, Quinoline, ZnMe2, LiOtBu, toluene, 120 oC, 3 h. (v) 30, 4-iodoanisole, NaOtBu, toluene/THF, 120 oC, 6 h. (vi) 39, allyl-MgBr, THF, −78 oC-rt, overnight.
