Fig. 6: MicroRNAs drive hGPC transcriptional maturation in tandem with transcription factor activity. | Nature Communications

Fig. 6: MicroRNAs drive hGPC transcriptional maturation in tandem with transcription factor activity.

From: Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells

Fig. 6

A. Principal component analysis of miRNA microarray samples from human A2B5+ adult and CD140a+ fetal GPCs (n = 4 biologically independent samples). B. Log2 fold change bar plots and heatmap of all differentially expressed miRNAs (FDR < 0.01, calculated in limma). C Characterization bubble plot of enrichment of miRNAs, versus the average log2 FC of its predicted gene targets. D, E Curated signaling networks of (D) fetal (top) and (E) adult (bottom) enriched miRNAs and their predicted targets. Source data are provided as a Source Data file. Error bars ± SEM.

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