Fig. 5: Systemic delivery of PMO/HDOs drastically improves the restraint-induced fear response. | Nature Communications

Fig. 5: Systemic delivery of PMO/HDOs drastically improves the restraint-induced fear response.

From: Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model

Fig. 5

a Detection of exon 23-skipped dystrophin mRNA in the whole brain of mdx mice 2 weeks after once weekly for a total of 5 doses of PMO or Chol-HDO (11.88 μmol/kg) (n = 4 per group). b Duration of tonic immobility (freezing) expressed as a percentage of freezing time (n = 4–6 per group). c Total horizontal movement distance traveled (distance run in 10 min) (n = 4–6 per group). d Representative trajectory diagram of B10 and mdx mice treated with PBS, PMOs, or Chol-HDO. Data are presented as mean ± S.E.M. a–c And were analyzed using one-way analysis of variance followed by Tukey’s Kramer tests (b, c). P-values are indicated. Source data are provided as a Source Data file.

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