Fig. 3: Adipocyte-specific knockout of Irf3 attenuates HFD-induced insulin resistance in mice at thermoneutrality. | Nature Communications

Fig. 3: Adipocyte-specific knockout of Irf3 attenuates HFD-induced insulin resistance in mice at thermoneutrality.

From: Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

Fig. 3

Metabolic analysis of male WT and FI3KO mice (n = 10) after 16 weeks of HFD feeding at thermoneutrality, including insulin tolerance test (a), glucose tolerance test (b), ad lib fed serum insulin levels (c), immunoblotting for P-AKT (S473) protein levels in eWAT, BAT, iWAT, muscle, and liver (d), in vivo 2-deoxyglucose uptake in BAT, iWAT, eWAT, quadriceps muscle and heart (e). Statistical significance was assessed by two-way ANOVA (a–c) or two-tailed Student’s t test (d, e). Data in all panels are expressed as mean ± SEM.

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