Fig. 8: Model of sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes. | Nature Communications

Fig. 8: Model of sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes.

From: Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

Fig. 8

Sleep fragmentation increases sympathetic innervation of the myocardium via SCG, releasing more norepinephrine, which indirectly inhibits VPS35 in cardiomyocytes, leading to ATP7A-associated impairment of copper transport, triggering intracellular copper overload and ultimately exacerbating myocardial ischemia-reperfusion injury. The figure was drawn by Figdraw (https://www.figdraw.com/#/) and Adobe Photoshop.

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