Fig. 1: Schematic diagram of the study. | Nature Communications

Fig. 1: Schematic diagram of the study.

From: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Fig. 1

a Design of the animal translocation experiment. Hu sheep (gray) and Tibetan sheep (black) originally inhabited low-altitude and high-altitude environments, respectively. There were three scenarios examined in our experiment: low-altitude Hu sheep raised in the lowlands (scenario 1); high-altitude Hu sheep, namely low-altitude Hu sheep that were translocated to the highlands (scenario 2) and acclimatized until four time points; and Tibetan sheep raised in highlands (scenario 3). In addition, offspring of the ewes in the above three scenarios were included. b Sample collection and data generation. We collected 19 whole-body tissues and produced phenotypic, genomic (WGS), transcriptomic (bulk-RNA, single-cell RNA), and epigenetic (ATAC-Seq) data. Tissue marked in red (i.e., heart) was used for generating WGS data. c Major bioinformatics and statistical analysis involved in the study.

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