Fig. 2: Characteristics of phenotype and gene expression. | Nature Communications

Fig. 2: Characteristics of phenotype and gene expression.

From: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Fig. 2

a Changes in blood oxygen saturation [SpO2, average value with 95% confidence interval (CI)] with acclimatization time. Hu sheep (n = 10): 0 d, 97.30 (CI: 96.68 − 97.92); 7 d, 82.51 (CI: 81.87 − 83.15); 14 d, 83.67 (CI: 82.68 − 84.66); 21 d, 85.38 (CI: 84.24 − 86.52); 8 mon, 87.0 (CI: 86.03 − 87.97); and Tibetan sheep (n = 10): 92.65 (CI: 91.68 − 93.62). Boxplots are represented by minima, 25% quantile, median, 75% quantile, and maxima with data points. b, c Changes in the nitric oxide synthetase (NOS) (b) and cardiac enzyme (CK) (c) values (average value with 95% CI) over time. In b, Hu sheep (n = 10): 0 d, 7.05 µmol/L (CI: 6.69 − 7.41); 7 d, 5.71 µmol/L (CI: 5.17 − 6.25); 14 d, 5.23 µmol/L (CI: 5.03 − 5.43); 21 d, 5.78 µmol/L (CI: 5.33 − 6.23); 8 mon, 5.43 µmol/L (CI: 5.07 − 5.79); and Tibetan sheep (n = 10), 6.40 µmol/L (CI: 5.88 − 6.92). In c, Hu sheep (n = 10): 0 d, 62.1 U/L (CI: 48.64 − 75.56); 7 d, 60.0 U/L (CI: 40.45 − 79.55); 14 d, 64.2 U/L (CI: 56.87 − 71.53); 21 d, 55.2 U/L (CI: 44.64 − 65.76); 8 mon, 53.3 U/L (CI: 44.91 − 61.69); and Tibetan sheep (n = 10), 146.7 U/L (CI: 69.15 − 224.25). P values in the figures a–c come from the two-sided Wilcoxon rank sum test. d t-distributed stochastic neighbor embedding (t-SNE) clustering of 1277 RNA-Seq samples. e Association between gene modules and bio-indicators in blood. The rows represent the 14 gene modules (i.e., M1-M14), and the columns show 19 bio-indicators. Multiple testing was corrected using the Benjamini-Hochberg method. * FDR < 0.05. f Gene Ontology (GO) analysis for M3. g Gene examples in M3. Scatter plots show the Pearson’s correlation between the expression levels of genes and the values of bio-indicators over time. The two-sided P values are calculated by the linear regression model. Source Data are provided as Source Data file.

Back to article page