Fig. 3: Transcriptome dynamics during hypoxia acclimatization. | Nature Communications

Fig. 3: Transcriptome dynamics during hypoxia acclimatization.

From: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Fig. 3

a Numbers of differentially expressed genes (DEGs) (top) and percentages of DEGs (bottom) between adjacent time points comparisons across tissues. b Distribution of DEGs across numerous tissues in the “0 d vs. 7 d” comparison. c, d Numbers of tissue-shared (c) and tissue-specific (d) DEGs across tissues in the “0 d vs. 7 d” comparison. e, f GO term enrichments for tissue-shared (e) and tissue-specific (f) DEGs from the “0 d vs. 7 d” comparison. g Multi-tissue interactions in the “0 d vs. 7 d” comparison. The average log2FC value for cluster 5 is denoted with a black line. Active tissues (i.e., cerebellum, kidney, and colon) are marked with asterisks, and the interaction of NOTCH1 between tissues is highlighted with a red line. h Numbers of dynamically changed genes (DCGs) across tissues. i Fuzzy c-means clustering identified gene expression patterns of DCGs in the cerebellum. j GO terms for the four clusters identified in (i). Source Data are provided as Source Data file.

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