Fig. 7: Time-series transcriptome of genes implicated in adaptation and disease in human. | Nature Communications

Fig. 7: Time-series transcriptome of genes implicated in adaptation and disease in human.

From: A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Fig. 7

a Conservation of transcripts of 14 common tissues in human and sheep. t-SNE clustering of samples in our study (n = 1277) and the human GTEx v8 consortium (n = 6792) based on batch-corrected expression. Species (left) and tissue types (right) are distinguished by color. b Hierarchical clustering of common tissues in humans and sheep based on Pearson’s correlation of the median TPM value. c, d Gene examples for human pulmonary hypertension (i.e., BMPR2) and high-altitude adaptation (i.e., HIF1A). c Pearson’s correlation between humans and sheep based on the median value of BMPR2 (left). Expression patterns of BMPR2 in crucial tissues over time (right). The two-sided P values are calculated by the linear regression model. Shading: standard error of the fitting line. d, Similar to c, but for the HIF1A gene. e The expression of BMPR2 and HIF1A across cell types in the lung. AT1, alveolar type 1 cell; AT2, alveolar type 2 cell. f The expression of HIF1A in club cells (top) and classic monocytes (bottom) over time in the lung with a single replicate (n = 1). Boxplots are represented by minima, 25% quantile, median, 75% quantile, and maxima. g Cell-cell communication results for differentially expressed cell types from BMPR2 and HIF1A in adjacent time point comparisons. FIB, fibroblast; CM, mast cell; CLI, ciliated cell; AM, alveolar macrophage; PTC, proferating T cell; VEC, vein endothelial; NEUT, neutrophil; MES, mesenchymal cell; MC, mast cell; IM, interstitial macrophage. h Transcription factors (TFs) regulating HIF1A and BMPR2. Source Data are provided as Source Data file.

Back to article page