Fig. 2: IDH1 R132Q has lower deuterium uptake than R132H in both binary and quaternary complexes. | Nature Communications

Fig. 2: IDH1 R132Q has lower deuterium uptake than R132H in both binary and quaternary complexes.

From: Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms

Fig. 2

A Plots of deuterium uptake encompassing residues 86–120, 168–182, and 269–291 (left) are shown with the structural features of these residues shown in cartoon (right) for IDH1 R132Q, WT13, and R132H14. B Plots of deuterium uptake for residues 168–191, 217–227, 257–267, and 305–354 (left) are shown, with the structural features of IDH1 R132Q, WT13, and R132H30 encompassing these regions indicated in cartoon (right). Each point represents the mean of three technical replicates.

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