Fig. 4: IDH1 R132Q bound to ICT, NADP(H) and Ca2+ is in a closed, catalytically competent conformation. | Nature Communications

Fig. 4: IDH1 R132Q bound to ICT, NADP(H) and Ca2+ is in a closed, catalytically competent conformation.

From: Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms

Fig. 4

A The R132Q:NADP(H):ICT:Ca2+ complex is shown with each monomer highlighted using a slight color change. B Monomer-based alignments of R132Q:NADP(H):ICT:Ca2+/R132Q:NADP(H):Ca2+ monomers (dark and light cyan) with WT:NADP(H):ICT:Ca2+13 (dark green); R132H:NADP(H):ICT30 (wheat); and R132H:NADP(H):αKG:Ca2+14 (dark purple). C For clarity, only the catalytic residues, residue R132X, cofactor, substrates, Ca2+ and hinge are shown in the same orientation for the structures shown in (B).

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