Fig. 7: Hydrogen bond network facilitates a “seatbelt” that overlays NADP(H) in only some quaternary structures of IDH1. | Nature Communications

Fig. 7: Hydrogen bond network facilitates a “seatbelt” that overlays NADP(H) in only some quaternary structures of IDH1.

From: Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms

Fig. 7

A Unlike the binary structure of IDH1 WT13 and quaternary structure of G97D:NADP(H):αKG:Ca2+14, the quaternary IDH1 WT complex13 forms a seatbelt over the NADP(H). B Binary R132Q:NADP(H) and quaternary R132Q:NADP(H):αKG:Ca2+ structures do not form a seatbelt, while R132Q:NADP(H):ICT:Ca2+ and the most closed conformation of R132Q:NADP-αKG:Ca2+ form a seatbelt. C No seatbelt is formed in the binary R132H:NADP(H), ternary R132H:NADP(H):ICT, or quaternary R132H:NADP(H):αKG:Ca2+ structures of IDH1 R132H14,30.

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