Fig. 5: Mapping matrisome interactions and associated germline functions.

a Top panel—Bar graph showing the impact of each gene family in the germ line, calculated by weighting the phenotype average based on the number of genes causing the phenotype. Left axis—Integrated weighted average. 0–4 = low to high impact. Bottom panel—balloon plot showing the distribution of genes causing phenotypes in each region of the germ line. Size of the circle = number of genes showing a phenotype. Color of the circle = percentage of genes in each family showing a phenotype. The numbers on the right of the plot shows the number of genes that cause phenotypes in multiple regions. b Map showing the curated interactions between matrisome genes with experimentally verified phenotype. Top schematic—network showing all the genes regulating the germ line that have previously curated STRING interactions. Blue lines show interactions between genes, and the red lines show the location of germ line functional impact. Each gene family represented by node color. Gene families with less than two members indicated as other. Bottom schematic—Map of matrisome RNAi phenotypes, mainly constituting CLECs, that did not reveal interactions with other matrisome genes in validated databases. Supplementary data associated to Fig. 5—Supplementary Data 5 and 10.