Fig. 2: Ablation of endogenous IL-22ra1 signaling in pancreatic β-cells leads to impaired glycemic tolerance with age. | Nature Communications

Fig. 2: Ablation of endogenous IL-22ra1 signaling in pancreatic β-cells leads to impaired glycemic tolerance with age.

From: Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

Fig. 2

a Experimental schematic, created with BioRender.com, released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license. b Pancreatic sections of β-cell IL-22ra1 knockout animals and their wildtype littermate counterparts stained for cre-recombinase, IL-22ra1 and Insulin. c Changes in glucose tolerance following oral glucose administration in animals with age. d Area under the curve during oral glucose tolerance tests in animals with age (16 weeks p = 0.0380; 20 weeks p = 0.0146). All graphs are presented as Mean ± SEM. Female animals; n = 7 biologically independent animals (8–16 weeks), 9 biologically independent animals (20 weeks), Two-tailed unpaired Student’s t-test. *p < 0.05; n.s., non-significant. *versus wildtype (IL-22rafl/fl) littermates. Scale Bar: 20 um. Source data are provided as a Source Data file.

Back to article page