Fig. 7: Summary of findings. | Nature Communications

Fig. 7: Summary of findings.

From: Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

Fig. 7

Graphical abstract of findings showing that ablation of pancreatic beta-cell IL-22ra1 signaling leads to increased islet cellular stress and MHC II expression, reduced islet regeneration and insulin biosynthesis, and hypersecretion of proinsulin during glucose stimulation. These factors contribute to the age-related hyperglycaemia observed in IL-22ra1ΔβKO animals. Figure created with BioRender.com, released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

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