Fig. 8: A working model of how IRE1α regulates cellular glutathione synthesis and sensitivity to ferroptosis. | Nature Communications

Fig. 8: A working model of how IRE1α regulates cellular glutathione synthesis and sensitivity to ferroptosis.

From: IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis

Fig. 8

GCLC Glutamate-Cysteine Ligase Catalytic Subunit, GCLM Glutamate-Cysteine Ligase Modifier Subunit, GPX4 Glutathione Peroxidase 4, GSS glutathione synthetase, LOOH lipid hydroxide, LOH alcohol, BSO buthionine sulfoximine. SLC3A2 Solute Carrier Family 3 Member 2. SLC7A11 Solute Carrier Family 7 Member 11.

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