Fig. 3: Association of 203 candidate HLA alleles with COVID-19 vaccine antibody response. | Nature Communications

Fig. 3: Association of 203 candidate HLA alleles with COVID-19 vaccine antibody response.

From: Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

Fig. 3

A Circular Manhattan plot of HLA-gene-based genetic analysis for the first-dose antibody response (left panel) and second-dose antibody response (right panel) in the discovery dataset. The red dashed circle indicates a threshold of P value of 0.05. B Association strength and direction of 15 HLA alleles that are significant in both the discovery and validation datasets following the false discovery rate correction of the total number of alleles tested. The upper portion of the panel represents the results for the first-dose antibody response, while the lower portion represents the second-dose antibody response. C Pairwise correlation plot between 15 significant HLA alleles. D Antibody positivity rate among individuals with varying copies of alleles (0, 1, 2) across seven independent and significant HLA genes. The left portion of the panel represents the results for the first-dose antibody response, while the right portion is for the second-dose antibody response.

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