Table 1 Baseline characteristics of eligible participants with the antibody test in the cross-sectional cohort

From: Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

 

First-dose vaccine recipients

Second-dose vaccine recipients

 

All

Discovery dataset

Validation dataset

All

Discovery dataset

Validation dataset

Number

107,175

97,097

10,078

67,825

61,013

6812

Age, mean (SD)

67.27 (7.59)

67.23 (7.60)

67.61 (7.53)

71.22 (6.56)

71.21 (6.57)

71.29 (6.50)

Age category, n (%)

 50–59 years

42,872 (40.0)

38,671 (39.8)

4201 (41.7)

45,931 (67.7)

41,302 (67.7)

4629 (68.0)

 60–69 years

19,970 (18.6)

18,223 (18.8)

1747 (17.3)

5085 (7.5)

4582 (7.5)

503 (7.4)

 ≥70 years

44,333 (41.4)

40,203 (41.4)

4130 (41.0)

16,809 (24.8)

15,129 (24.8)

1680 (24.7)

Sex, n (%)

 Female

59,761 (55.8)

54,584 (56.2)

5177 (51.4)

39,417 (58.1)

35,733 (58.6)

3684 (54.1)

 Male

47,414 (44.2)

42,513 (43.8)

4901 (48.6)

28,408 (41.9)

25,280 (41.4)

3128 (45.9)

Ethnicity

      

 White

90,511 (84.5)

81,825 (84.3)

8686 (86.2)

56,814 (83.8)

50,933 (83.5)

5881 (86.3)

 Others

16,664 (15.5)

15,272 (15.7)

1392 (13.8)

11,011 (16.2)

10,080 (16.5)

931 (13.7)

Weeks since the latest vaccination, n (%)

 1 week

1677 (1.6)

1513 (1.6)

164 (1.6)

13,222 (19.5)

11,941 (19.6)

1281 (18.8)

 2 weeks

2957 (2.8)

2683 (2.8)

274 (2.7)

12,911 (19.0)

11,624 (19.1)

1287 (18.9)

 3 weeks

4609 (4.3)

4173 (4.3)

436 (4.3)

10,715 (15.8)

9675 (15.9)

1040 (15.3)

 4 weeks

7053 (6.6)

6408 (6.6)

645 (6.4)

8939 (13.2)

7963 (13.1)

976 (14.3)

 5 weeks

9188 (8.6)

8361 (8.6)

827 (8.2)

7018 (10.3)

6295 (10.3)

723 (10.6)

 6 weeks

10,489 (9.8)

9558 (9.8)

931 (9.2)

4989 (7.4)

4483 (7.3)

506 (7.4)

 7 weeks

12,350 (11.5)

11,171 (11.5)

1179 (11.7)

3426 (5.1)

3068 (5.0)

358 (5.3)

 8 weeks

14,840 (13.8)

13,424 (13.8)

1416 (14.1)

2438 (3.6)

2211 (3.6)

227 (3.3)

 9 weeks

15,613 (14.6)

14,088 (14.5)

1525 (15.1)

1718 (2.5)

1543 (2.5)

175 (2.6)

 10 weeks

14,655 (13.7)

13,263 (13.7)

1392 (13.8)

1275 (1.9)

1153 (1.9)

122 (1.8)

 11 weeks

11,319 (10.6)

10,272 (10.6)

1047 (10.4)

733 (1.1)

650 (1.1)

83 (1.2)

 12 weeks

2425 (2.3)

2183 (2.2)

242 (2.4)

441 (0.7)

407 (0.7)

34 (0.5)

Vaccine types, n (%)a

 ChAdOx1

39,948 (37.3)

36,366 (37.5)

3582 (35.5)

18,578 (27.4)

16,721 (27.4)

1857 (27.3)

 BNT162b2

15,188 (14.2)

13,690 (14.1)

1498 (14.9)

17,587 (25.9)

15,886 (26.0)

1701 (25.0)

 Unknown

52,039 (48.6)

47,041 (48.4)

4998 (49.6)

31,660 (46.7)

28,406 (46.6)

3254 (47.8)

  1. aCalculated based on a subgroup of participants who had complete linkage to primary care records for information on COVID-19 vaccine types.