Table 2 Effect of vaccine-induced antibody response on breakthrough COVID-19 outcomes

From: Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes

Exposure

Breakthrough outcomes

Number of HLA alleles

Relative risk (95% CI)

Effectiveness (95% CI)

First-dose antibody response

COVID-19 infection

6

0.83 (0.74 to 0.94)

16.84 (6.39 to 26.12)

Severe COVID-19

6

0.55 (0.36 to 0.84)

49.94 (15.52 to 70.34)

Second-dose antibody response

COVID-19 infection

2

0.78 (0.65 to 0.94)

21.68 (5.99 to 34.76)

Severe COVID-19

2

0.54 (0.28 to 1.01)

46.44 (−1.49 to 71.73)

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