Fig. 7: Elevated PPIA and NRF2 accumulation is positively associated with poor prognosis in NSCLC patients.
From: PPIA dictates NRF2 stability to promote lung cancer progression
A Representative immunohistochemical analysis of PPIA and NRF2 in human LUAD tissue microarray containing lung tumor tissues and adjacent normal lung tissues. Scale bar = 50 μm. B Scatter plots showing a positive correlation of PPIA and NRF2 expression in IHC analysis of human NSCLC cancer tissues (n = 69 samples). Linear regression with Pearson R and two-tailed P values are shown. C Kaplan-Meier survival curves of patients with NSCLC divided by high or low PPIA protein expression level according to IHC analysis (n = 69 samples). D Kaplan-Meier survival curves of patients with NSCLC divided by high or low NRF2 protein expression level according to IHC analysis (n = 69 samples). E–H Kaplan–Meier survival curves of patients with NSCLC based on PPIA, NRF2, KLF5 and SLC1A5 gene expression level (for PPIA, n = 719 samples; for NRF2, n = 672 samples; for KLF5, n = 719 samples; for SLC1A5, n = 719 samples). Data are integrated from Kaplan–Meier plotter (http://kmplot.com/analysis/). Statistical significance for Kaplan–Meier survival curves (C–H) was calculated by Log-rank (Mantel-Cox) test. Source data are provided as a Source Data file.
